Edvard Smith is Professor at the Dept of Molecular Genetics, Karolinska Institutet, Sweden & Stockholms Laens Landsting.
CRC is a research hotel facility hoasted by SLL. The research groups at CRC has highly qualified staffs consisting of physicians, molecular biologists, cell biologists and engineers. Research activities in the Smith/Zain group are focused on rare diseases caused by increased number of nucleotide repeats. Using oligonucleotides to target non-B-DNA structures in the genome, the aim is to increase or decrease the expression from the disease-causing gene. Additional areas of interest are the development of new diagnostic methods through non-PCR based sequencing and studies on the effect of BTK inhibitors on B-cell malignancies.
The group has full access to state-of-the-art molecular biology laboratories, with equipment for oligonucleotide transfer, such as particle measurement NanoSight apparatus, UV-crosslinking equipment and cell culture rooms, microscopy and fully equipped GMP facilities.