ESR Project 3
Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Centre National de la Recherche Scientifique (CNRS), Aix-Marseille University, Marseille, France
Functional dendrimer nanosystems for oligonucleotides delivery
Jing WU obtained her Bachelor’s Degree in Chemistry at the Nanchang University, China.
During her undergraduate years, her research projects mainly focussed on modifying mesoporous silica for drug delivery and synthesizing aggregation-induced emission materials for optical imaging under the supervision of Prof. Xiaoyong ZHANG.
Subsequently, she studied for a Master’s Degree in medicinal chemistry at the Wuhan university (China). As part of her final Master’s thesis, she developed a novel Near infrared II (NIR-II) probe to target osteosarcoma for fluorescence and photoacoustic imaging under the supervision of Prof. Xuechuan HONG.
Through the Master and Bachelor research projects, she has acquired solid knowledge and skills in chemistry, biology and medical science.
The aim of this ESR PhD project will be the development and optimization of dendrimer nanovectors for ON delivery. In this project, various amphiphilic dendrimers for ON delivery will be designed and synthesized. These dendrimers will be then studied for their self-assembling and complexing with ONs to form nanosized complexes in the view to protecting ONs from degradation and promoting cellular uptake of ONs. The resulting biological effects of the delivered ONs will be evaluated in vitro using cell-based experiments and in vivo using animal models of cardiovascular diseases, Huntington disease and cancers in collaboration with AstraZenaca (AZ) and Stockholms Laens Landsting (SLL) through secondments in partner organizations.
This project is carried out in strong collaboration with the following groups:
Dr. Carlo Vascotto, University of Udine, Italy
Prof. Edvard Smith and Prof Rula Zain, Stockholms Laens Landsting, Sweden
Dr. Shalini Andersson, AstraZeneca, Sweden
Research activities in the group of Dr. Ling PENG in CINaM-CNRS are focused on developing dendrimer nanotechnology-based delivery systems for nucleic acid therapeutics. The laboratory has all the key facilities and expertise in synthesizing, characterizing and evaluating the dendrimer molecules and nanosystems for ON delivery. The host institute has full access to NMR, MS, HPLC, DLS, TEM, cell culture and all the necessary infrastructure and arrangement in place to host Jing Wu.
Centre Interdisciplinaire de Nanoscience de Marseille
Aix-Marseille University, CNRS, UMR 7325 CINaM
163, Avenue de Luminy