Quentin Vicentini

The aim of this ESR PhD project is the evaluation of different alternatives for enhancement of mRNA transcription:

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• RNA activation that affects the transcription of mRNA as well as targeting of miRNAs that suppress mRNA transcription, the latter in collaboration with KI.

• ON constructs for enhancement of mRNA transcription, processing and translation. This involves ONs that affect splice switching and activation of transcription by ONs targeting microRNAs that suppress transcription in collaboration with KI and SLL.

• ONs conjugated to multiple entities for increased efficacy of ON therapy, including entities for increased tissue specificity and cell uptake, will be evaluated in vitro in relevant cell types especially for protein replacement therapy for cardiometabolic disease.

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During secondments in partner organizations Quentin will extend his knowledge on the effect of ONs derivatization and modification on RNA transcription or translation.

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Secondments

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This project is carried out in strong collaboration with the following groups:

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• Prof. Roger Strömberg, Karolinska Institutet, Sweden

• Prof. Edvard Smith, SLL, Sweden

• Dr. Sean Lim, Prof. Alex Mirnezami, Southampton Cancer Centre (UHSFT), Southampton, UK

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Project summary in 3 min